Corneal infection and inflammation studies

About the Project

Research2The cornea is an avascular specialized type of barrier tissue that maintains an immune privileged status through an active innate and restricted adaptive immune response. Our goals are to understand how the corneal proteoglycans regulate innate immune response in the context of infections and wound healing. Lumican interacts with CD14, an adaptor protein that conveys bacterial lipopolysaccharides to TLR4 and promotes induction of pro-inflammatory cytokines and phagocytosis of gram-negative bacteria.  We recently identified antimicrobial peptidoglycan recognition proteins in the corneal epithelium Pglyrp1-4; their roles in bacterial infections of the cornea are under investigation as well.

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